Does acquisitions impact the firm’s technological development? A study using knowledge base in the pharmaceutical industry

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Murilo Montanari de Matos
https://orcid.org/0000-0003-4141-4958
Ana Paula Macedo de Avellar

Abstract

This article focuses on the acquisition of small pharmaceutical firms (SPHF) by large pharmaceutical firms (LPHF). LPHFs enlarge their own knowledge base by incorporating their target’s knowledge base. Given this scenario we pose the question: Is it possible to link knowledge acquired via an acquisition to technological development? In order to answer this question we developed an approach that allows the impact of a target’s knowledge base to be observed in the acquirer’s own knowledge base. This objective was achieved qualitatively, based on a sample of 8 LPHFs and 51 SPHFs. Our main conclusions were: (i) the dissemination of biotechnologies is boosted by acquisition; (ii)  acquisitions have allowed  the  knowledge bases of LPHFs to assimilate  their target’s knowledge bases; (iii) the target’s patents offer a great potential for developing technologies that are already dominated by the LPHF; and (iv) the “incorporation” of scientists from target companies allows LPHFs to internalize research lines. Our main contribution is to link knowledge base characteristics to potential directions taken in the technological development process.

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How to Cite
MONTANARI DE MATOS, M. .; MACEDO DE AVELLAR, A. P. Does acquisitions impact the firm’s technological development? A study using knowledge base in the pharmaceutical industry . RAE - Revista de Administracao de Empresas , [S. l.], v. 62, n. 2, p. 1–20, 2022. DOI: 10.1590/S0034-759020220206. Disponível em: https://periodicos.fgv.br/rae/article/view/85505. Acesso em: 30 jun. 2024.
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References

Ahuja, G., & Katila, R. (2001). Technological acquisition and the innovation performance of acquiring firms: A longitudinal study. Strategic Management Journal, 22(3), 197-220. doi: 10.1002/smj.157

Ahuja, G., & Lampert, C. M. (2001). Entrepreneurship in the large corporation: A longitudinal study of how established firms create breakthrough inventions. Strategic Management Journal, 22(6-7), 521-543. doi: 10.1002/smj.176

Andersson, M., & Xiao, J. (2016). Acquisitions of start-ups by incumbent businesses: A market selection process of “high-quality” entrants? Research Policy, 45(1), 272-290. doi: 10.1016/j.respol.2015.10.002

Asheim, B. & Gertler, M. S. (2005), ‘The Geography of Innovation; Regional innnovation systems’, in Fagerberg, J., Mowery, D. and Nelson, R.R. (eds.), The Oxford Handbook of Innovation, Norfolk, Oxford University Press.

Asheim, B., Coenen, L., & Vang, J. (2007). Constructing knowledge-based regional advantage: Implications for regional innovation policy. International Journal of Entrepreneurship and Innovtion Management, 7(5), 140-155. doi: 10.1504/IJEIM.2007.012879

Asheim, B., & Hansen, H. (2009). On the usefulness of the creative class. Economic Geography, 85(9) p424-442. doi: 10.1111/j.1944-8287.2009.01051.x

Boschma, R. (2005). Proximity and innovation: A critical assessment. Regional Studies, 39(1), 61-74. doi: 10.1080/0034340052000320887

Bryan, K., Ozcan, Y., & Sampat, B. (2020). In-text patent citations: A user's guide. Research Policy, 49(4), 103946. doi: /10.1016/j.respol.2020.103946

Chakrabarti, A., Hauschildt, J., & Sürverkrüp, C. (1994). Does it pay to acquire technological firms? R&D Management, 1(24), 47-56. doi:10.1111/j.1467-9310.1994.tb00846.x

Chen, I. J., Hsu, P. H., Officer, M. S., & Wang, Y. (2020). The Oscar goes to…: High-tech firms’ acquisitions in response to rivals’ technology breakthroughs. Research Policy, 49(7), 104078. doi: 10.1016/j.respol.2020.104078

Cloodt, M., Hagedoorn, J., & Kranenburg, H. Van. (2006). Mergers and acquisitions: Their effect on the innovative performance of companies in high-tech industries. Research Policy, 35(5), 642-654. doi: 10.1016/j.respol.2006.02.007

Cohen, W. M., & Levinthal, D. A. (1989). Innovation and learning: The two faces of R&D, The Economic Journal 99(397), 569-596. doi: 10.2307/2233763

Cohen, W. M., & Levinthal, D. A. (1990). Absorptive capacity: A new perspective on and innovation learning. Administrative Science Quarterly – Special Issue: Technology, 35(1), 128-152. doi: 10.2307/2393553

Colombo, M. G., & Grilli, L. (2005). Founders’ human capital and the growth of new technology-based firms: A competence-based view. Research Policy, 34(6), 795-816. doi: 10.1016/j.respol.2005.03.010

Colombo, M. G., & Piva, E. (2012). Firms’ genetic characteristics and competence-enlarging strategies: A comparison between academic and non-academic high-tech start-ups. Research Policy, 41(1), 79-92. doi: 10.1016/j.respol.2011.08.010

Desyllas, P., & Hughes, A. (2007). Sourcing technological knowledge through corporate acquisition: Evidence from an international sample of high technology firms. Journal of High Technology Management Research, 18(2), 157-172. doi: 10.1016/j.hitech.2007.12.003

Desyllas, P., & Hughes, A. (2010). Do high technology acquirers become more innovative? Research Policy, 39(8), 1105-1121. doi: 10.1016/j.respol.2010.05.005

Giovanni Dosi. (1988). Sources, Procedures, and Microeconomic Effects of Innovation. Journal of Economic Literature, 26(3), 1120–1171. Retrieved from http://www.jstor.org/stable/2726526

Ejdemo, T., & Örtqvist, D. (2020). Related variety as a driver of regional innovation and entrepreneurship: A moderated and mediated model with non-linear effects. Research Policy, 49(7), 104073. doi: 10.1016/j.respol.2020.104073

Eliasson, K., Hansson, P., & Lindvert, M. (2017). Effects of foreign acquisitions on R&D and high-skill activities. Small Business Economics, 49(1), 163-187. doi: 10.1007/s11187-016-9815-9

Fernandes, C., Farinha, L., Ferreira, J., Asheim, B., & Rutten, R. (2020). Regional innovation systems: What can we learn from 25 years of scientific achievements? Regional Studies, 55(1), 1-13. doi:10.1080/00343404.2020.1782878

Gerpott, T. J. (1995). Successful integration of R&D functions after acquisitions: An exploratory empirical study. R&D Management, 25(2), 161-178. doi: 10.1111/j.1467-9310.1995.tb00909.x

Grigoriou, K., & Rothaermel, F. T. (2014). Structural microfoundations of innovation: The role of relational stars. Journal of Management, 40(2), 586-615. doi: 10.1177/0149206313513612

Grillitsch, M., Schubert, T., & Srholec, M. (2019). Knowledge base combinations and firm growth. Research Policy, 48(1), 234-247. doi: 10.1016/j.respol.2018.08.009

Hagedoorn, J., & Duysters, G. (2002). External sources of innovative capabilities: The preference for strategic alliances or mergers and acquisitions. Journal of Management Studies, 39(2), 167-188. doi: 10.1111/1467-6486.00287

Hall, B. H. (2004). Exploring the patent explosion. The Journal of Technology Transfer, 30(1-2), 35-48. doi:10.1007/s10961-004-4356-9

Hall, B. H., Jaffe, A. B., & Trajtenberg, M. (2001). The NBER patent citations data file: Lessons, insights and methodological tools. National Bureau of Economic Research, NBER, No Title Working Paper n. 8498.

Hall, B. H., Jaffe, A., & Trajtenberg, M. (2005). Market value and patent citations. RAND Journal of economics, 16-38. Retrieved from http://www.jstor.org/stable/1593752

Henderson, R., Jaffe, A. B., & Trajtenberg, M. (1998). Universities as a source of commercial technology: A detailed analysis of university patenting, 1965–1988. Review of Economics and Statistics, 80(1), 119-127. doi: 10.1162/003465398557221

Hohberger, J. (2016). Does it pay to stand on the shoulders of giants? An analysis of the inventions of star inventors in the biotechnology sector. Research Policy, 45(3), 682-698. doi: 10.1016/j.respol.2015.12.003

Houston, J., G.; Banks, M. (1997). The Chemical-biological interface: developments in automated and miniaturized screening technology. In: Current Opinion in Biotechnology, 8, pp 734-740.

Hussinger, K. (2010). On the importance of technological relatedness: SMEs versus large acquisition targets. Technovation, 30(1), 57-64. doi: 10.1016/j.technovation.2009.07.006

Lange, S., & Wagner, M. (2019). The influence of exploratory versus exploitative acquisitions on innovation output in the biotechnology industry. Small Business Economics, 52(2), 1-229. doi: 10.1007/s11187-019-00194-1

Lerner, J. (1994) The importance of patent scope: an empirical analysis RAND. Journal of Economics, 25(2), 319. doi: 10.2307/2555833

Makri, M., Hitt, M. A., & Lane, P. (2010). Friends, acquaintances, or strangers? Partner selection in R&D alliances. Strategic Management Journal, (31), 602-628. doi: 10.5465/amj.2008.31767271

Malerba, F., & McKelvey, M. (2016). Conceptulizing knowledge intensive entrepreneurship: Definition and model. In F. Malerba, Y. Caloghirou, M. Mckelvey, & S. Radosevic (Eds.), Dynamics of knowledge-intensive entrepreneurship: Business strategy and public policy. ´p. 19-48. New York: Routledge.

Malerba, F., & McKelvey, M. (2020). Knowledge-intensive innovative entrepreneurship integrating Schumpeter, evolutionary economics, and innovation systems. Small Business Economics, 54(2), 503-522. doi: 10.1007/s11187-018-0060-2

Malerba, F., & Orsenigo, L. (2015). The evolution of the pharmaceutical industry. Business History, 57(5), 664-687. doi:10.1007/s11187-018-0060-2

Matos, M. M. de (2016). Changes in Innovation Dynamics of the Pharmaceutical Industry: A Study of the Interaction between Large pharmaceutical Companies and the Acquired Small Biotechnology Enterprises. Tese (Doutorado) – Unicamp, Campinas, 2016.

Matos, M. M. de (2020). Incorporação de conhecimento por meio de aquisições na indústria farmacêutica: uma análise focada nos inventores das patentes. Revista Brasileira de Inovação, 19, p. e0200016. doi: 10.20396/rbi.v19i0.8658178

Mokyr, J. (2002). The gifts of Athena: Historical origins of the knowledge economy. Princeton, New Jersey: Princeton University Press.

Nelson, R., & Winter, S. (1982). An Evolutionary Theory of Economic Change. Belknap Press of Havard University Press: Cambridge MA.

Nightingale, P. (1998). A cognitive model of innovation. Research Policy, 27(7), 689-709.

Nightingale, P. (2000). Economies of scale in experimentation: Knowledge and technology in pharmaceutical R&D. Industrial & Corporate Change, 9(2), 315. doi: 10.1093/icc/9.2.315

Nightingle, P., & MARTIN, P. (2004). The myth of the biotec revolution. In: Trends in Biotechnology, vol. 22, n. 11. doi: 10.1016/j.tibtech.2004.09.010

Norbäck, P. J., Persson, L., & Tåg, J. (2014). Acquisitions, entry, and innovation in oligopolistic network industries. International Journal of Industrial Organization, 37, 1-12. doi: 10.1016/j.ijindorg.2014.07.003

Novelli, E. (2015). An examination of the antecedents and implications of patent scope. Research Policy, 44(2), 493-507. doi: 10.1016/j.respol.2014.09.005

Oettl, A. (2012). Reconceptualizing stars: Scientist helpfulness and peer performance. Management Science, 58(6), 1122-1140. doi: 10.1287/mnsc.1110.1470

Organization for Economic Cooperation and Development. (2013). OECD Science, Technology and Industry Scoreboard 2013. OECD.

Pereira, D. A., & Williams, J. A. (2007). Origin and evolution of high throughput screening. British Journal of Pharmacology, 152(1), 53-61. doi: 10.1038/sj.bjp.0707373

Quéré, M. The post-genome era: rupture in the organization of the life science industry? In: Mckelvey, M., Rickne, A., Laage-Hellman, J. The Economic Dynamics of Modern Biotechnology, Edward Elgar, Northhampton, USA, 2004

Shapin, S. (2018). The scientific revolution. University of Chicago Press.

Sharp, M. (1996). Knowledge transfer and biotechnology. Knowledge, technology transfer and foresight, NATO Asi Series, pp. 3-24. Dordrecht: Springer.

Shkolnykova, M., & Kudic, M. (2021). Who benefits from SMEs’ radical innovations? Empirical evidence from German biotechnology. Small Business Economics, 1-29. doi: 10.1007/s11187-021-00464-x

Strumsky, D., & Lobo, J. (2015). Identifying the sources of technological novelty in the process of invention. Research Policy, 44(8), 1445-1461. doi: 10.1016/j.respol.2015.05.008

Szücs, F. (2014). M&A and R&D: Asymmetric effects on acquirers and targets? Research Policy, 43(7), 1264-1273. doi: 10.1016/j.respol.2014.03.007

Trajtenberg, M., Henderson, R., & Jaffe, A. (1997). University versus corporate patents: A window on the basicness of invention. Economics of Innovation and New Technology, 5(1), 19-50. doi: 10.1080/10438599700000006

Verhoeven, D., Bakker, J., & Veugelers, R. (2016). Measuring technological novelty with patent-based indicators. Research Policy, 45(3), 707-723. doi: 10.1016/j.respol.2015.11.010

Wagner, M. (2011). To explore or to exploit? An empirical investigation of acquisition by large incumbents. Research Policy, 40(9), 1217–1225. doi: 10.1016/j.respol.2011.07.006

Xiao, J. (2015). The effects of acquisition on the growth of new technology-based firms: Do different types of acquirers matter ? Small Business Economics, (45), 487-504. doi: 10.1007/s11187-015-9656-y

Zucker, L. G., & Darby, M. R. (1997). Present at the biotechnological revolution: Transformation of technological identity for a large incumbent pharmaceutical firm. Research Policy, 26(4-5), 429-446. doi: 10.1016/S0048-7333(97)00017-6